Paraptosis triggers mitochondrial pathway-mediated apoptosis in Alzheimer's disease

Human galectin-1 triggers apoptosis via ceramide mediated mitochondrial pathway

Effects of Diamond nanoparticles on mitochondrial apoptosis pathway in rats with testicular ischemia / reperfusion.

Background and Aim: Testicular torsion is a urological emergency that leads to testicular tissue damage and infertility. In recent years, several studies have been conducted on the antioxidant properties of nanoparticles. The aim of this study was to investigate the effects of Diamond nanoparticles on the  apoptosis in rats with testicular ischemia / reperfusion. Methods: 48 adult rats aged 20 ...

Ichthyotoxic Cochlodinium polykrikoides Induces Mitochondrial Mediated Oxidative Stress and Apoptosis in Rat Liver Hepatocytes

In this research, we investigated the cytotoxic mechanisms of Cochlodinium polykrikoidescell lysate on isolated rat liver hepatocytes.This micro algae is responsible for a severe and widespread harmful algal bloom in the Persian Gulf and Gulf of Oman (2008-2009). Isolated hepatocytes were obtained by collagenase perfusion of Sprague-Dawley rat liver.According to our results, incubation of algal...

Mitochondrial DNA damage triggers mitochondrial-superoxide generation and apoptosis.

Recently, it has become apparent that mitochondrial DNA (mtDNA) damage can rapidly initiate apoptosis independent of mutations, although the mechanism involved remains unclear. To elucidate this mechanism, angiotensin II-mediated apoptosis was studied in cells that were transduced with a lentiviral vector to overexpress the DNA repair enzyme 8-oxoguanine glycosylase or were treated with inhibit...

Ichthyotoxic Cochlodinium polykrikoides Induces Mitochondrial Mediated Oxidative Stress and Apoptosis in Rat Liver Hepatocytes

In this research, we investigated the cytotoxic mechanisms of Cochlodinium polykrikoidescell lysate on isolated rat liver hepatocytes.This micro algae is responsible for a severe and widespread harmful algal bloom in the Persian Gulf and Gulf of Oman (2008-2009). Isolated hepatocytes were obtained by collagenase perfusion of Sprague-Dawley rat liver.According to our results, incubation of algal...